Capsule Filling Problems can significantly reduce production efficiency, increase material waste, and lead to batch rejection in pharmaceutical manufacturing. This guide explains the most common capsule filling defects, including separation failures, weight variation, powder spillage, closing defects, and ejection problems. It also provides practical troubleshooting methods, preventive maintenance strategies, and equipment optimization recommendations to help manufacturers improve product quality, minimize downtime, maintain cGMP compliance, and achieve stable, high-efficiency capsule production.